α-klotho reduces susceptibility to osteoarthritis: evidence from cross-sectional studies and Mendelian randomization.

ABSTRACT:

Background

Despite extensive research, the association between serum α-klotho levels and osteoarthritis (OA) remains unclear, predominantly relying on findings from OA mouse models. This study used data from the National Health and Nutrition Examination Survey (NHANES) to conduct a cross-sectional study examining the relationship between α-klotho and human OA. In addition, we used Mendelian randomization (MR) to genetically infer a causal relationship between serum α-klotho and the three OA subtypes.

Method

A cohort of 12,037 subjects from NHANES (2007-2016) was analyzed. Multivariate logistic regression was utilized to examine the association between α-klotho concentration and OA, alongside subgroup analysis and interaction tests. Additionally, a two-sample bi-directional M

SUBMITTER: Li Z 

PROVIDER: S-EPMC11611571 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature