Genomic tools for post-elimination measles molecular epidemiology using Canadian surveillance data from 2018-2020.

ABSTRACT:

Introduction

Measles is caused by the highly infectious measles virus, MeV, for which there is an effective vaccine. Monitoring of progress of measles elimination requires enhanced surveillance and tracking of MeV strains, including documenting the absence of an endemically circulating strain. Due to a reduction in the number of circulating genotypes, additional sequence information, beyond the standardized 450 nucleotide window of the nucleoprotein (N450), is required to corroborate the information from epidemiological investigations and, ideally, fill in gaps in the surveillance data.

Methods

This study applies MeV sequencing tools, namely the N450, the non-coding region between the matrix and fusion genes (MF-NCR), and the complete coding sequence of the genome (WGS-t), t

SUBMITTER: Hiebert J 

PROVIDER: S-EPMC11611582 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature