Hepatocellular Carcinoma Etiology Drives Survival Outcomes: A Population-Based Analysis.

ABSTRACT:

Background

Previous survival studies on hepatocellular carcinoma (HCC) by etiology are limited to hospital-based series, restricted cohorts, and monolithic etiologic categories. We studied population-based survival by seven mutually exclusive HCC etiologic groups-standalone hepatitis-C virus (HCV), hepatitis-B virus (HBV), alcohol-related liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), and dual etiology HCV-HBV, HCV-ALD, and HBV-ALD-accounting for clinical and sociodemographic characteristics.

Methods

All HCC cases diagnosed during 2005 to 2018 from the Florida Cancer Registry were linked for etiology using statewide discharge and viral hepatitis data. We performed a cause-specific survival analysis including Cox regression for the matched 15,616 cases by HCC

SUBMITTER: Cranford HM 

PROVIDER: S-EPMC11611647 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature