Nasal virus infection induces asthma exacerbation through B-cell-dependent recruitment of inflammatory monocytes.

ABSTRACT:

Background

Upper respiratory viral infections (URVIs) are responsible for 80% of asthma exacerbation episodes. However, the underlying mechanisms remain poorly understood.

Methods

In this study, we used a mouse model of URVI and examined the impact of URVI on asthma phenotypes and the underlying mechanisms.

Results

Previously, we have reported that nasal-restricted infection with respiratory syncytial virus (RSV) only produces mild sino-nasal inflammation and mucus production, without causing direct lung infection. However, such nasal-restricted infection dramatically enhanced T_H2 and T_H17 inflammatory responses in the lungs and increased airway hyperresponsiveness (AHR) in mice with house dust mite (HDM)-induced asthma. Additionally, nasal-restr

SUBMITTER: Waldstein KA 

PROVIDER: S-EPMC11611691 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature