Post-thaw CD34+ cell recovery likely degraded under extreme graft platelet concentrations.

ABSTRACT: Impaired post-thaw CD34 cell (postCD34) viability in autologous haematopoietic stem cell transplant (ASCT) could indicate delayed engraftment where multiple factors might complicate the relationship. Despite of a couple of unconfirmed reports of a negative correlation of platelet concentration with postCD34 viability, how platelets might be involved in the relationship is largely unknown. Therefore, this question was addressed in this retrospective study of 82 ASCT patients with a total of 150 collections of peripheral blood stem cells in New Zealand. A significant negative correction between platelet concentration and postCD34 recovery (r = -0.18, p = 0.028) was observed overall, but upon further analysis only confirmed in the subset with graft platelets 1500-2000 ×10⁹/L. Impor

SUBMITTER: Duarte GC 

PROVIDER: S-EPMC11611725 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature