The association between inflammatory cytokines and sarcopenia-related traits: a bi-directional Mendelian randomization study.

ABSTRACT:

Background

Sarcopenia is among the most common musculoskeletal illnesses, yet its underlying biochemical mechanisms remain incompletely understood. Identifying the relationship of inflammatory cytokines with sarcopenia components would help understand the etiology of sarcopenia. We performed a bi-directional Mendelian randomization study to explore the causal relationship between 41 inflammatory cytokines and sarcopenia-related traits.

Methods

The study was performed in two stages using bidirectional dual-sample Mendelian randomization. We obtained aggregated statistical data on inflammatory factors, low grip strength, and ALM from genome-wide association studies. To explore the causal association between exposure and outcomes, we primarily utilized the inverse variance weig

SUBMITTER: Wang J 

PROVIDER: S-EPMC11611733 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature