Disruption of the C5a/C5aR1 axis confers protection against hookworm infection in lung.

ABSTRACT: Hookworms are soil-transmitted parasitic nematodes that penetrate the host skin before migrating to the lungs. With an estimated 500-700 million people infected worldwide, hookworm infections are a neglected tropical disease and a significant cause of morbidity, particularly in children, pregnant women, and immunocompromised individuals. Although there is ample evidence that complement activation is pivotal to elicit a protective host immune response against invasive pathogens, its role in hookworm infection remains insufficiently explored. Here, we investigated the complement anaphylatoxin, C5a, during the early lung stage of infection with Nippostrongylus brasiliensis in C57BL/6J wild type and C5aR1^-/- mice. Despite the previously reported ability of lung larvae to evad

SUBMITTER: Walachowski S 

PROVIDER: S-EPMC11611822 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature