Prognostic significance and gene co-expression network of CD16A and FGL2 in gliomas.

ABSTRACT:

Introduction

The CD16A protein encoding gene FcγRIIIa (FCGR3A) and its potential ligand Fibrinogen-like protein 2 (FGL2) are involved in various cell physiological activities on the extracellular surface. Aberrant expression of these genes has been linked to tumorigenesis.

Methods

To assess the prognostic significance of FCGR3A and FGL2 transcription expression in glioma and explore their roles in glioma initiation and progression, we utilized multiple online databases, including TCGA, GEPIA, CGGA, cBioPortal, TISCH, LinkedOmics, Ivy Glioblastoma Atlas Project, and Human Protein Atlas.

Results

Our analysis revealed that FCGR3A and FGL2 expression was significantly correlated with clinical variables such as age, tumor type, WHO

SUBMITTER: Cao Z 

PROVIDER: S-EPMC11611834 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature