Automated in-situ monitoring of accelerated crystallization processes of nifedipine using terahertz time-domain spectroscopy.

ABSTRACT: We developed and tested an automated measurement platform which can fit multiple samples for their investigation in transmission mode using terahertz time-domain spectroscopy. The temperature inside the platform can be varied to simulate different storage conditions of the samples, in our case, pharmaceuticals. As a proof-of-concept, the setup was successfully tested to monitor the crystallization process of amorphous nifedipine, as a model drug, at 24 °C, 30 °C and 35 °C for over 144 h. To the best of our knowledge, this is the first study to follow the crystallization of nifedipine with quasi-continuous measurements over a time frame of several days. The influence of the storage temperature on the crystallization rate was monitored including the appearance of polymorphic intermediate sta

SUBMITTER: Heidrich L 

PROVIDER: S-EPMC11611916 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature