Fazekas scale magnetic resonance imaging assessment in Alzheimer's disease and primary age-related tauopathy.

ABSTRACT:

Background

Brain vascular pathology is an important comorbidity in Alzheimer's disease (AD), with white matter damage independently predicting cognitive impairment. However, it is still unknown how vascular pathology differentially impacts primary age-related tauopathy (PART) compared to AD. Therefore, our objectives were to compare the brain microangiopathic burden in patients with PART and AD, evaluated by MRI, while assessing its relation with neuropathological findings, patterns of brain atrophy and degree of clinical impairment.

Methods

Clinical information, brain MRI (T1 and T2-FLAIR) and neuropathological data were obtained from the National Alzheimer's Coordinating Centre ongoing study, with a total sample of 167 patients identified, that were divided according to th

SUBMITTER: Quintas-Neves M 

PROVIDER: S-EPMC11611984 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature