Determination of promising inhibitors for N-SH2 domain of SHP2 tyrosine phosphatase: an in silico study.

ABSTRACT: There are many genes that produce proteins related to diseases and these proteins can be targeted with drugs as a potential therapeutic approach. Recent advancement in drug discovery techniques have created new opportunities for treating variety of diseases by targeting disease-related proteins. Structure-based drug discovery is a faster and more cost-effective approach than traditional methods. SHP2 phosphatase, encoded by the PTPN11 gene, has been the focus of much attention due to its involvement in many types of diseases. The biological function of SHP2 is enabled mostly by protein-protein interaction through its SH2 domains. In this study, we report the identification of a potential small molecule inhibitor for the N-SH2 domain of SHP2 by structure-based drug discovery approach. We ut

SUBMITTER: Gencer Akcok EB 

PROVIDER: S-EPMC11612003 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature