Subtype-specific transcription factors affect polyamine metabolism and the tumor microenvironment in breast cancer.

ABSTRACT:

Background

Polyamines play important roles in cell growth and proliferation. Polyamine metabolism genes are dysregulated in various tumors. Some polyamine metabolism genes are regulated by transcription factors. However, the transcription factors that regulate polyamine metabolism genes have not been completely identified. Additionally, whether any of the transcriptional regulations depend on tumor heterogeneity and the tumor microenvironment has not been investigated.

Methods

We used bulk RNA-seq data to identify dysregulated polyamine metabolism genes and their transcription factors across breast cancer subtypes. Genes highly correlated with polyamine changes were obtained, and their subtype-specific expressions were checked in tumor microenvironment cells using single-cel

SUBMITTER: Song Q 

PROVIDER: S-EPMC11612022 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature