The interaction of family functioning and disease- and treatment-related factors on quality of life for children after cancer.

ABSTRACT:

Purpose

Children with cancer experience low quality of life (QOL), yet heterogeneity underscores a need to understand how risk and resilience factors interact. This study evaluated if family functioning relates to QOL differentially depending on diagnosis and treatment intensity.

Methods

Participants included children (ages 8-14) who completed treatment within six months for either brain tumor (BT; n = 42) or non-central nervous system solid tumor (ST; n = 29). Caregivers and children rated QOL and family functioning. Treatment intensity was categorized as low, moderate, or high. Cross-informant moderation models tested hypothesized interactions.

Results

Child-reported family functioning significantly interacted with diagnosis and treatment intensity in

SUBMITTER: Moscato EL 

PROVIDER: S-EPMC11612033 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature