The predictive, preventive, and personalized medicine of depression: gut microbiota and inflammation.

ABSTRACT:

Background

Gut microbiota (GM) is closely associated with the onset of depression, in which inflammation plays an essential role. Identifying specific GM associated with depression and their mechanisms, based on the principles of predictive, preventive, and personalized medicine (PPPM), is a critical step toward achieving targeted prevention and personalized treatment for depression.

Working hypothesis and methodology

We hypothesized that both gut microbiota (GM) and cytokines influence the onset of depression, with cytokines acting as mediators of GM effects on depression. To test this hypothesis, we employed univariate Mendelian Randomization (UVMR) analysis to identify GM taxa associated with depression and cytokines and to determine the potential role of the identified G

SUBMITTER: Wu J 

PROVIDER: S-EPMC11612071 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature