PET imaging of GABA_A receptors in pancreatic islets by [¹¹C]flumazenil.

ABSTRACT:

Background

Type 1 diabetes (T1D) is an autoimmune disease characterized by a progressive β-cell destruction. There are no clinically established methods for quantifying endocrine cells of the pancreas and current knowledge is almost exclusively based on autopsy material and functional measurements. Based on the expression of the γ-aminobutyric acid A receptors (GABA_ARs) in pancreatic islets and the fact that GABA_AR agonists are being explored as treatment for T1D, we hypothesized that the positron emission tomography (PET) tracer [¹¹C]flumazenil ([¹¹C]FMZ) could serve as a marker of the endocrine mass of the pancreas. The in vivo uptake of [¹¹C]FMZ in pig pancreas was evaluated by PET/CT, either tracer alone or after blockade o

SUBMITTER: Maloum-Rami F 

PROVIDER: S-EPMC11612099 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature