FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases.

ABSTRACT: The development of antiviral strategies is a key task of biomedical research, but broad-spectrum virus inhibitors are scarce. Here we show that fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors reduce infection of several cell types with DNA and RNA viruses by blocking early stages of infection, but not viral cell association. Unexpectedly, their antiviral activity was largely independent of FGFR kinase inhibition. RNA profiling showed upregulation of interferon response genes by FGFR inhibitors, but their expression did not correlate with the antiviral activity in infected cells. Using bioinformatics analysis of kinome data, targeted kinase assays, siRNA-mediated knock-down and pharmacological inhibition experiments, we show that blockade of Src family kinases, in partic

SUBMITTER: Stefanova D 

PROVIDER: S-EPMC11612106 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature