Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research.

ABSTRACT: Lyme disease is caused by an infection with the spirochete Borrelia burgdorferi, and is the most common vector-borne disease in North America. B. burgdorferi isolates harbor extensive genomic and proteomic variability and further comparison of isolates is key to understanding the infectivity of the spirochetes and biological impacts of identified sequence variants. Here, we applied both transcriptome analysis and mass spectrometry-based proteomics to assemble peptide datasets of B. burgdorferi laboratory isolates B31, MM1, and the infective isolate B31-5A4, to provide a publicly available Borrelia PeptideAtlas. Included are total proteome, secretome, and membrane proteome identifications of the individual isolates. Proteomic data collected from 35 different experiment datasets, totaling 38

SUBMITTER: Reddy PJ 

PROVIDER: S-EPMC11612207 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature