Insights into the pharmaceutical properties and in silico study of novel hydrazone derivatives.

ABSTRACT: It has been established that the Hydrazone derivatives have important pharmacological effects. In the first step, hydrazine (NH₂NH₂) reacts with a compound containing a carbonyl group (C = O) in the presence of ethanol and heat, leading to the formation of hydrazone compound (H1). The second step is the formation of the Schiff base (H2) by the reaction of compound (H1) with indole, ethanol, and acetic acid, which contain a double bond (C = N). In the third step, the (H1) reacts with thiophene, ethanol, and acetic acid to form a compound (H3) containing multiple bonds between the indole and thiophene rings. The synthetic test compounds underwent characterization using TLC, IR, 1 H - NMR, and ¹³C NMR spectral examinations. Both compounds, H2 and H3, exhibit a

SUBMITTER: Ibraheem HH 

PROVIDER: S-EPMC11612229 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature