Portable, low-field magnetic resonance imaging for evaluation of Alzheimer's disease.

ABSTRACT: Portable, low-field magnetic resonance imaging (LF-MRI) of the brain may facilitate point-of-care assessment of patients with Alzheimer's disease (AD) in settings where conventional MRI cannot. However, image quality is limited by a lower signal-to-noise ratio. Here, we optimize LF-MRI acquisition and develop a freely available machine learning pipeline to quantify brain morphometry and white matter hyperintensities (WMH). We validate the pipeline and apply it to outpatients presenting with mild cognitive impairment or dementia due to AD. We find hippocampal volumes from ≤ 3 mm isotropic LF-MRI scans have agreement with conventional MRI and are more accurate than anisotropic counterparts. We also show WMH volume has agreement between manual segmentation and the automated pipeline. The incr

SUBMITTER: Sorby-Adams AJ 

PROVIDER: S-EPMC11612292 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature