Handling delayed or missed direct oral anticoagulant doses: model-informed individual remedial dosing.

ABSTRACT:

Abstract

Nonadherence to direct oral anticoagulant (DOAC) pharmacotherapy may increase the risk of thromboembolism or bleeding, and delayed or missed doses are the most common types of nonadherence. Current recommendations from regulatory agencies or guidelines regarding this issue lack evidence and fail to consider individual differences. This study aimed to develop individual remedial dosing strategies when the dose was delayed or missed for DOACs, including rivaroxaban, apixaban, edoxaban, and dabigatran etexilate. Remedial dosing regimens based on population pharmacokinetic (PK)-pharmacodynamic (PD) modeling and simulation strategies were developed to expeditiously restore drug concentration or PD biomarkers within the therapeutic range. Population PK-PD characteristics of DOAC

SUBMITTER: Liu XQ 

PROVIDER: S-EPMC11612359 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature