Misalignment Between Circadian Preference and Accelerometer-Derived Sleep-Wake Cycle With Increased Risk of Cardiometabolic Diseases.

ABSTRACT:

Background

The relationship of circadian misalignment, sleep-wake cycle, and cardiometabolic diseases (CMDs) remains unclear.

Objectives

This prospective study investigated the associations between circadian misalignment and CMDs, including type 2 diabetes (T2D), coronary heart disease (CHD), and stroke, and explored potential mechanisms.

Methods

Data from 60,965 participants without pre-existing CMDs from the UK Biobank study and followed for an average of 7.9 years were analyzed. Circadian misalignment was determined by comparing self-reported chronotype and accelerometer-derived sleep timing. Incident CMDs were documented via multiple medical registries and self-reported information. Cox proportional hazards models were applied to estimate HRs and 95% CIs for these

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11612363 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature