Proteogenomic analysis dissects early-onset breast cancer patients with prognostic relevance.

ABSTRACT: Early-onset breast cancer is known for its aggressive clinical characteristics and high prevalence in East Asian countries, but a comprehensive understanding of its molecular features is still lacking. In this study, we conducted a proteogenomic analysis of 126 treatment-naïve primary tumor tissues obtained from Korean patients with young breast cancer (YBC) aged ≤40 years. By integrating genomic, transcriptomic, and proteomic data, we identified five distinct functional subgroups that accurately represented the clinical characteristics and biological behaviors of patients with YBC. Our integrated approach could be used to determine the proteogenomic status of HER2, enhancing its clinical significance and prognostic value. Furthermore, we present a proteome-based homologous recombination d

SUBMITTER: Yoon KA 

PROVIDER: S-EPMC11612404 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature