Immunoinformatics design of a multi-epitope vaccine for Chlamydia trachomatis major outer membrane proteins.

ABSTRACT: Chlamydia trachomatis (CT) remains a significant infectious cause of blindness and sexually transmitted infections worldwide. The objective and novelty of this study lie in using different serovars of CT to design a broad-spectrum multi-epitope vaccine that might confer immunity against different CT infections. As the major outer membrane protein in CT has good immunodominance properties and high conservation and also determines the several serotypes of CT, it is selected as an antibody target in this study. T-cell and B-cell epitopes from serovars A, B, D, E, L1, and L2 were predicted and combined into a single construct by incorporating adjuvants and linkers to enhance immunogenicity and stability. Physicochemical characterization confirmed the constructed vaccine's anti-allergic, immuno

SUBMITTER: Shetty S 

PROVIDER: S-EPMC11612408 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature