Causal relationship between inflammatory factors and gynecological cancer: a Bayesian Mendelian randomization study.

ABSTRACT:

Background

Cervical cancer, ovarian cancer, and endometrial cancer are the three most common cancers in gynecology. Understanding their respective pathology is currently incomplete. Inflammatory factors play an important role in the pathophysiology of these three cancers, but the causal relationship between inflammatory factors and these three cancers is unclear.

Methods

Based on publicly available genetic databases, relevant instrumental variables were extracted according to predefined thresholds, and causal analyses of CRP, 41 circulating inflammatory factors, and three gynecological cancers were performed, mainly using the inverse variance weighted method, while bayesian analysis was performed to improve the accuracy of the results. Finally, heterogeneity, horizontal plei

SUBMITTER: Dang C 

PROVIDER: S-EPMC11612437 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature