Mapping the relative accuracy of cross-ancestry prediction.

ABSTRACT: The overwhelming majority of participants in genome-wide association studies (GWAS) have European (EUR) ancestry, and polygenic scores (PGS) derived from EURs often perform poorly in non-EURs. Previous studies suggest that between-ancestry differences in allele frequencies and linkage disequilibrium are significant contributors to the poor portability of PGS in cross-ancestry prediction. We hypothesize that the portability of (local) PGS varies significantly over the genome. Therefore, we develop a method, MC-ANOVA, to estimate the loss of accuracy in cross-ancestry prediction attributable to allele frequency and linkage disequilibrium differences between ancestries. Using data from the UK Biobank we develop PGS relative accuracy (RA) maps quantifying the local portability of EUR-derived P

SUBMITTER: Lupi AS 

PROVIDER: S-EPMC11612447 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature