The transcription factor BBX regulates phosphate homeostasis through the modulation of FGF23.

ABSTRACT: Fibroblast growth factor 23 (FGF23) plays an important role in phosphate homeostasis, and increased FGF23 levels result in hypophosphatemia; however, the molecular mechanism underlying increased FGF23 expression has not been fully elucidated. In this study, we found that mice lacking the bobby sox homolog (Bbx^-/-) presented increased FGF23 expression and low phosphate levels in the serum and skeletal abnormalities such as a low bone mineral density (BMD) and bone volume (BV), as well as short and weak bones associated with low bone formation. Osteocyte-specific deletion of Bbx using Dmp-1-Cre resulted in similar skeletal abnormalities, elevated serum FGF23 levels, and reduced serum phosphate levels. In Bbx^-/- mice, the expression of sodium phosphate cotransporter 2a (

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC11612488 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature