Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders.

ABSTRACT:

Aims

Anxiety disorders are prevalent and anxiety symptoms (ANX) co-occur with many psychiatric disorders. We aimed to identify genomic loci associated with ANX, characterize its genetic architecture, and genetic overlap with psychiatric disorders.

Methods

We included a genome-wide association study of ANX (meta-analysis of UK Biobank and Million Veterans Program, n = 301,732), schizophrenia (SCZ), bipolar disorder (BIP), major depression (MD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD), and validated the findings in the Norwegian Mother, Father, and Child Cohort (n = 95,841). We employed the bivariate causal mixture model and local analysis of covariant association to characterize the genetic architecture including overlap between the

SUBMITTER: Tesfaye M 

PROVIDER: S-EPMC11612548 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature