Novel spin-lock time sampling strategies for improved reproducibility in quantitative T1ρ mapping.

ABSTRACT: This study aimed to optimize the sampling of spin-lock times (TSLs) in quantitative T1ρ mapping for improved reproducibility. Two new TSL sampling schemes were proposed: (i) reproducibility-guided random sampling (RRS) and (ii) reproducibility-guided optimal sampling (ROS). They were compared to the existing linear sampling (LS) and precision-guided sampling (PS) schemes for T1ρ reproducibility through numerical simulations, phantom experiments, and volunteer studies. Each study evaluated the four sampling schemes with three commonly used T1ρ preparations based on composite and balanced spin-locking. Additionally, the phantom and volunteer studies investigated the impact of B₀ and B₁ field inhomogeneities on T1ρ reproducibility, respectively. The reproducibility was a

SUBMITTER: Jogi SP 

PROVIDER: S-EPMC11612825 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature