Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Importance

Metals are established neurotoxicants, but evidence of their association with cognitive performance at low chronic exposure levels is limited.

Objective

To investigate the association of urinary metal levels, individually and as a mixture, with cognitive tests and dementia diagnosis, including effect modification by apolipoprotein ε4 allele (APOE4).

Design, setting, and participants

The multicenter prospective cohort Multi-Ethnic Study of Atherosclerosis (MESA) was started from July 2000 to August 2002, with follow-up through 2018. A total of 6303 MESA participants were included. Data analysis was performed from October 12, 2023, to June 13, 2024.

Exposure

Urine samples were collected at baseline (2000-2002), and arsenic, cadmium, cobalt, copper, lea

SUBMITTER: Domingo-Relloso A 

PROVIDER: S-EPMC11612832 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature