Differential temporal decline of cerebral oxytocin and μ-opioid receptor density during the aging process in mice.

ABSTRACT: Aging is often associated with changes in social, sexual, emotional and pain functioning, as well as with the increased prevalence of certain psychopathologies. However, the neurodevelopmental basis underpinning these age-related changes remains to be determined. Considering the key roles of oxytocin (OTR) and μ-opioid (MOPr) receptor systems in regulating social, sexual, pain, reward and emotional processing, it seems plausible that they are also implicated in age-related behavioural alterations. Although the ontogeny of both receptors has been well characterized in rodent brains from early development till adulthood, little is known concerning the neuroadaptations occurring from middle age to old age. Therefore, we mapped the neuroadaptations in OTR and MOPr in the brains of mice at thos

SUBMITTER: Effah F 

PROVIDER: S-EPMC11612844 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature