β-Blocker Use and Delayed Onset and Progression of Huntington Disease.

ABSTRACT:

Importance

Huntington disease (HD) is characterized by motor, cognitive, and psychiatric decline. β-Blockers may play a therapeutic role by decreasing enhanced sympathetic tone in HD.

Objective

To evaluate the impact of β-blockers on the timing of motor diagnosis onset and progression of HD symptoms.

Design, setting, and participants

This observational, longitudinal multicenter study used the Enroll-HD platform database (initiated September 2011 to present), including propensity score-matched cohorts of patients with premanifest HD (preHD) and early motor-manifest HD (mmHD) who were either users or nonusers of β-blockers. Participants included patients with genetically confirmed preHD (n = 4683 eligible participants) or mmHD (n = 3024 eligible participants) who were t

SUBMITTER: Schultz JL 

PROVIDER: S-EPMC11612910 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature