Impaired Dynamics of Positional and Contextual Neural Coding in an Alzheimer's Disease Rat Model.

ABSTRACT:

Background

The hippocampal representation of space, formed by the collective activity of populations of place cells, is considered as a substrate of spatial memory. Alzheimer's disease (AD), a widespread severe neurodegenerative condition of multifactorial origin, typically exhibits spatial memory deficits among its early clinical signs before more severe cognitive impacts develop.

Objective

To investigate mechanisms of spatial memory impairment in a double transgenic rat model of AD.

Methods

In this study, we utilized 9-12-month-old double-transgenic TgF344-AD rats and age-matched controls to analyze the spatial coding properties of CA1 place cells. We characterized the spatial memory representation, assessed cells' spatial information content and direction-specific

SUBMITTER: Nataraj A 

PROVIDER: S-EPMC11612983 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature