Integrating network pharmacology and Mendelian randomization to explore potential targets of matrine against ovarian cancer.

ABSTRACT:

Background

Matrine has been reported inhibitory effects on ovarian cancer (OC) cell progression, development, and apoptosis. However, the molecular targets of matrine against OC and the underlying mechanisms of action remain elusive.

Objective

This study endeavors to unveil the potential targets of matrine against OC and to explore the intricate relationships between these targets and the pathogenesis of OC.

Methods

The effects of matrine on the OC cells (A2780 and AKOV3) viability, apoptosis, migration, and invasion was investigated through CCK-8, flow cytometry, wound healing, and Transwell analyses, respectively. Next, Matrine-related targets, OC-related genes, and ribonucleic acid (RNA) sequence data were harnessed from publicly available databases. Differentially

SUBMITTER: Chen X 

PROVIDER: S-EPMC11613084 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature