Mathematical multi-compartment modeling of chronic lymphocytic leukemia cell kinetics under ibrutinib.

ABSTRACT: The Bruton tyrosine kinase inhibitor ibrutinib is an effective treatment for patients with chronic lymphocytic leukemia (CLL). While it rapidly reduces lymph node and spleen size, it initially increases the number of lymphocytes in the blood due to cell redistribution. A previously published mathematical model described and quantified those cell kinetics. Here, we propose an alternative mechanistic model that outperforms the previous model in 26 of 29 patients. Our model introduces constant subcompartments for healthy lymphocytes and benign tissue and treats spleen and lymph nodes as separate compartments. This three-compartment model (comprising blood, spleen, and lymph nodes) performed significantly better in patients without a mutation in the IGHV gene, indicating a diverse response to

SUBMITTER: Schulz M 

PROVIDER: S-EPMC11613170 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature