Alert prescribing of clozapine: a comparison of five drug-drug interaction sources.

ABSTRACT:

Introduction

Clozapine, an antipsychotic used in the treatment of schizophrenia, is known for its serious side effects. In order to promote patient safety, drug-drug interaction (DDI) databases can be consulted by clinicians. In this study, the degree of consensus between five sources on DDIs with clozapine is determined.

Methods

The summary of product characteristics of clozapine, Delphicare interaction database, Stockley's interaction checker, the Lexicomp interaction database, and the interaction database of Clinical Pharmacology are included. By comparing the original categories assigned to interactions with clozapine by the included DDI sources, a degree of consensus between sources is determined. Furthermore, based on the combined information, an evaluation on the seve

SUBMITTER: Govaerts J 

PROVIDER: S-EPMC11613245 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature