Roundabout Mechanism of Ion-Molecule Nucleophilic Substitution Reactions.

ABSTRACT: Roundabout (RA) is an important indirect mechanism for gas-phase X^- + CH₃Y → XCH₃ + Y^- S_N2 reactions at a high collision energy. It refers to the rotation of the CH₃-group by half or multiple circles upon the collision of incoming nucleophiles before substitution takes place. The RA mechanism was first discovered in the Cl^- + CH₃I S_N2 reaction to explain the energy transfer observed in crossed molecular beam imaging experiments in 2008. Since then, the RA mechanism and its variants have been observed not only in multiple C-centered S_N2 reactions, but also in N-centered S_N2 reactions, proton transfer reactions, and elimination reactions. This work reviewed recent studies

SUBMITTER: Wu X 

PROVIDER: S-EPMC11613305 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature