Catalytic Concerted S_NAr Reactions of Fluoroarenes by an Organic Superbase.

ABSTRACT: We herein propose that the catalytic concerted S_NAr reaction is a powerful method to prepare functionalized aromatic scaffolds. Classic stepwise S_NAr reactions involving addition/elimination processes require the use of electron-deficient aromatic halides to stabilize Meisenheimer intermediates, despite their widespread use in medicinal chemistry research. Recent efforts have been made to develop concerted S_NAr reactions involving a single transition state, allowing the use of electron-rich substrates based on the use of stoichiometric amounts of strong bases or reactive nucleophiles. This study demonstrates that, without the use of such reagents, the organic superbase t-Bu-P4 efficiently catalyzes the concerted S_NAr reactions of aryl fluo

SUBMITTER: Shigeno M 

PROVIDER: S-EPMC11613311 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature