Predicting allergen immunotherapy efficacy based on early maintenance phase response in routine clinical practice.

ABSTRACT:

Background

While allergen-specific immunotherapy (AIT) is acknowledged as an effective treatment, its efficacy varies, and consensus on predictive indicators for AIT responders remains elusive.

Objective

This study aimed to identify alternative parameters for predicting AIT responders based on clinical data collected in daily practice.

Method

We conducted a retrospective analysis of patients with house-dust-mite-driven asthma and/or rhinitis who completed 3 years of subcutaneous AIT (3y-AIT). We assessed the efficacy of AIT using the estimated daily symptom and medication score (edSMS) during different treatment periods, including up-dosing, maintenance I, II, and III phases. These scores were derived from detailed records of symptoms and medication use for AIT inject

SUBMITTER: Qin R 

PROVIDER: S-EPMC11613417 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature