General Alkene 1,2-<i>syn</i>-Cyano-Hydroxylation Procedure Via Electrochemical Activation of Isoxazoline Cycloadducts.

ABSTRACT: Stereoselective alkene 1,2-difunctionalization is a privileged strategy to access three-dimensional C(sp³)-rich chiral molecules from readily available "flat" carbon feedstocks. State-of-the-art approaches exploit chiral transition metal-catalysts to enable high levels of regio- and stereocontrol. However, this is often achieved at the expense of a limited alkene scope and reduced generality. 1,3-Dipolar cycloadditions are routinely used to form heterocycles from alkenes with high levels of regioselectivity and stereospecificity. Nevertheless, methods for the ring-opening of cycloadducts to reveal synthetically useful functionalities require the use of hazardous reagents or forcing reaction conditions; thus limiting their synthetic applications. Herein, we describe the implement

SUBMITTER: Wanderley TAS 

PROVIDER: S-EPMC11613428 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature