Interplay of Stereochemistry and Charge Governs Guest Binding in Flexible Zn^II₄L₄ Cages.

ABSTRACT: Here, we report the synthesis of a family of chiral Zn^II₄L₄ tetrahedral cages by subcomponent self-assembly. These cages contain a flexible trialdehyde subcomponent that allows them to adopt stereochemically distinct configurations. The incorporation of enantiopure 1-phenylethylamine produced Δ₄ and Λ₄ enantiopure cages, in contrast to the racemates that resulted from the incorporation of achiral 4-methoxyaniline. The stereochemistry of these Zn^II₄L₄ tetrahedra was characterized by X-ray crystallography and chiroptical spectroscopy. Upon binding the enantiopure natural product podocarpic acid, the Zn^II stereocenters of the enantiopure Δ₄-Zn^II₄L₄ cag

SUBMITTER: Xue W 

PROVIDER: S-EPMC11613429 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature