Expression quantitative trait loci influence DNA damage-induced apoptosis in cancer.

ABSTRACT:

Background

Genomic instability and evading apoptosis are two fundamental hallmarks of cancer and closely linked to DNA damage response (DDR). By analyzing expression quantitative trait loci (eQTL) upon cell stimulation (called exposure eQTL (e²QTL)) it is possible to identify context specific gene regulatory variants and connect them to oncological diseases based on genome-wide association studies (GWAS).

Results

We isolate CD8⁺ T cells from 461 healthy donors and stimulate them with high doses of 5 different carcinogens to identify regulatory mechanisms of DNA damage-induced apoptosis. Across all stimuli, we find 5,373 genes to be differentially expressed, with 85% to 99% of these genes being suppressed. While upregulated genes are specific to distinct

SUBMITTER: Bigge J 

PROVIDER: S-EPMC11613471 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature