NF-κB associated markers of prognosis in early and metastatic triple negative breast cancer.

ABSTRACT:

Background

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. While PD-1 based immunotherapies overall have led to improved treatment outcomes for this disease, a diverse response to frontline chemotherapy and immunotherapy still exist in TNBC, highlighting the need for more robust prognostic markers.

Methods

Tumor-intrinsic immunotranscriptomics, serum cytokine profiling, and tumor burden studies were conducted in two syngeneic mouse models to assess differential effects in both the early-stage and metastatic setting. Bioinformatic analyses of both early and metastatic TNBC patient data were performed to assess if identified NF-κB-associated factors are associated with improved patient clinical outcomes.

Results

NF-κB signaling driv

SUBMITTER: De La Cruz P 

PROVIDER: S-EPMC11613493 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature