Different patterns of longitudinal changes in antinuclear antibodies titers in children with systemic lupus erythematosus and Sjogren's syndrome.

ABSTRACT:

Objective

to investigate the trend of autoantibody titers during a 2-year follow-up in pediatric systemic lupus erythematosus (pSLE) and pediatric Sjögren's syndrome (pSS).

Methods

Autoantibodies testing was performed every 3-4 months during 2 years from disease onset in a cohort of children with pSLE and pSS.

Results

We enrolled 21 children with pSLE and 22 children with pSS. All pSLE patients at 2 years showed ANA titers significantly lower compared to disease onset. Eleven patients (73%) were still ANA positive at 2 years, while 4 (26%) became ANA negative. At diagnosis, 12 (80%) patients showed a homogeneous pattern, while 3 (20%) patients showed a speckled pattern. The latter remained ANA positive with the same pattern; only 2 patients with a homogenous pattern c

SUBMITTER: Moran Alvarez P 

PROVIDER: S-EPMC11613521 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature