Collision-Induced Dissociations of Linear Hexose and Disaccharides with Linear Hexose at the Reducing End.

ABSTRACT: Characterization of carbohydrate structures using mass spectrometry is a challenging task. Understanding the dissociation mechanisms of carbohydrates in the gas phase is crucial for characterizing these structures through tandem mass spectrometry. In this study, we investigated the collision-induced dissociation (CID) of glucose, galactose, and mannose in their linear forms, as well as the linear forms of hexose at the reducing end of 1-6 linked disaccharides, using quantum chemistry calculations and tandem mass spectrometry. Our results suggest that the dehydration reaction in linear structures is unlikely to occur due to the significantly high reaction barrier compared to those of C═O migration and C-C bond cleavage. We demonstrate that the different intensities of the cross-ring fragmen

SUBMITTER: Nguan HS 

PROVIDER: S-EPMC11613545 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature