Per- and polyfluoroalkyl substances, apolipoproteins and the risk of coronary heart disease in US men and women.

ABSTRACT:

Background

Existing evidence for associations of per- and polyfluoroalkyl substances (PFASs) with blood lipids, lipoproteins and apolipoproteins (apo), and coronary heart disease (CHD) risk is limited and inconsistent. This study aims to explore associations between plasma PFASs, blood lipoprotein subspecies defined by apolipoproteins, and CHD risk.

Methods

A case-control study of CHD was conducted in the Health Professionals Follow-Up Study (HPFS) and Nurses' Health Study (NHS). Among participants initially free of cardiovascular disease at blood collection in 1994 (HPFS) or 1990 (NHS), 101 participants who developed non-fatal myocardial infarction or fatal CHD were identified and confirmed. A healthy control was matched to each case for age, smoking status, and date of blo

SUBMITTER: Zhu L 

PROVIDER: S-EPMC11613683 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature