Trifluoromethylthiolation Carbonylation of Unactivated Alkenes via Distal Migration.

ABSTRACT: Sulfur-containing compounds represent a significant category of organic compounds, and the introduction of sulfur groups into organic compounds can effectively enhance their biological activity and synthetic diversity. Although a variety of difunctionalization reactions of alkenes based on sulfur radicals have been documented, significant challenges remain in the carbonylative difunctionalization of unactivated alkenes by the addition of a sulfur radical. Herein, we present a trifluoromethylthiolative carbonylation reaction of unactivated alkenes, which goes through the addition of a trifluoromethylthiol radical to unactivated alkenes and then carbonylation of the newly generated carbon radical intermediate. A heterocyclic/aryl migration in the presence of carbon monoxide is crucial for th

SUBMITTER: Miao RG 

PROVIDER: S-EPMC11613685 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature