Depleting parenchymal border macrophages alleviates cerebral edema and neuroinflammation following status epilepticus.

ABSTRACT:

Background

Status epilepticus (SE) is a common severe neurological emergency. Cerebral edema caused by SE is unavoidable and may exacerbate epilepsy. Recent studies have identified cerebrospinal fluid (CSF) as a crucial fluid source of initial cerebral edema following ischemic stroke and cardiac arrest. Moreover, synchronized neuronal firings drive CSF influx into interstitial fluid (ISF). Parenchymal border macrophages (PBMs) have been found to play a role in regulating CSF flow dynamics. However, the involvement of CSF and PBMs in cerebral edema during SE remains unclear. Here, we investigated the fluid source of cerebral edema in the initial phase of SE with the role of PBMs involved.

Methods

Lithium chloride-pilocarpine was used to induce SE in C57BL/6 J mice. Electroenc

SUBMITTER: Lin R 

PROVIDER: S-EPMC11613707 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature