Development and validation of the Vanderbilt PRS-KS, an instrument to quantify polygenic risk score knowledge.

ABSTRACT:

Purpose

As polygenic risk scores (PRSs) enter clinical practice, health care providers' and the publics' comprehension of PRS results are of great importance; yet, they are poorly understood. We present the Vanderbilt polygenic risk scores knowledge scale (Vanderbilt PRS-KS), a tool to quantify PRS knowledge.

Methods

The Vanderbilt PRS-KS was developed by a team of genetic counselors and physicians to cover key conceptual facts pertaining to PRSs. We recruited (n = 500) individuals with demographics representative of a U.S. sample and graduate-level health care students (n = 74) at a large academic medical center to participate in this validation study. We evaluated the Vanderbilt PRS-KS's psychometric properties using confirmatory factor analysis and item resp

SUBMITTER: Stubbs D 

PROVIDER: S-EPMC11613715 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature