Resistant and refractory migraine - two different entities with different comorbidities? Results from the REFINE study.

ABSTRACT:

Background

Resistant and refractory migraine are commonly encountered in specialized headache centers. Several comorbidities, mostly psychiatric conditions, have been linked to migraine worsening; however, there is little knowledge of the comorbidity profile of individuals with resistant and refractory migraine.

Methods

REFINE is a prospective observational multicenter international study involving individuals with migraine from 15 headache centers. Participants were categorized into three groups based on the European Headache Federation criteria: non-resistant and non-refractory (NRNRM), resistant (ResM), and refractory (RefM). We explored the prevalence of 20 comorbidities at baseline in the three groups.

Results

Of the 689 included patients (82.8% women), 262 (38.0

SUBMITTER: Rosignoli C 

PROVIDER: S-EPMC11613769 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature