Shared and distinct alterations in brain morphology in children with ADHD and obesity: Reduced cortical surface area in ADHD and thickness in overweight/obesity.

ABSTRACT:

Objective

To investigate shared versus distinct differences in brain structure among children with ADHD and obesity, we examined the morphology of regions implicated in cognitive control and reward function in a single cross-sectional cohort of children with and without ADHD and overweight/obesity (OV/OB).

Method

Participants included 471 children ages 8-12 years with ADHD (n = 244; 58 OV/OB) and neurotypical (NT) controls (n = 227; 81 OV/OB) classified as healthy-weight (HW; BMI %ile 5th to <85th) vs. having OV/OB (BMI %ile≥85th). Structural MRI was performed to obtain measures of cortical and subcortical morphology and compared across ADHD × BMI groups.

Results

Surface area was generally lower in ADHD vs. NT including in anterior cingulate cortex (ACC), dorsolateral

SUBMITTER: Rosch KS 

PROVIDER: S-EPMC11613793 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature